WASHINGTON (NEXSTAR) — Mitch McConnell, the longest-serving Senate leader in history, will step down from that position in November.

McConnell, who turned 82 last week, announced his decision Wednesday in the well of the Senate, a place where he looked in awe from its back benches in 1985 when he arrived.

“One of life’s most underappreciated talents is to know when it’s time to move on to life’s next chapter,” he said, “so I stand before you today…to say that this will be my last term as Republican leader of the Senate.”

His decision punctuates a powerful ideological transition underway in the Republican Party, from Ronald Reagan’s brand of traditional conservatism and strong international alliances, to the fiery, often isolationist populism of former President Donald Trump.

McConnell said he plans to serve out his Senate term, which ends in January 2027. Aides said McConnell’s announcement about the leadership post was unrelated to his health. The Kentucky senator had a concussion from a fall last year and two public episodes where his face briefly froze while he was speaking.

The senator had been under increasing pressure from the restive, and at times hostile, wing of his party that has aligned firmly with Trump. The two have been estranged since December 2020, when McConnell refused to abide Trump’s lie that the election of Democrat Joe Biden as president was the product of fraud.

McConnell gave no specific reason for the timing of his decision, which he has been contemplating for months, but he cited the recent death of his wife’s youngest sister as a moment that prompted introspection. “The end of my contributions are closer than I’d prefer,” McConnell said.

Trump has pulled the party hard to the ideological right, questioning longtime military alliances such as NATO, international trade agreements and pushing for a severe crackdown on immigration, all the while clinging to the falsehood that the election was stolen from him in 2020.

McConnell and Trump had worked together in Trump’s first term, remaking the Supreme Court and the federal judiciary in a far more conservative image, and on tax legislation. But there was also friction from the start, with Trump frequently sniping at the senator.

Their relationship has essentially been over since Trump refused to accept the results of the Electoral College. But the rupture deepened dramatically after the Jan. 6, 2021, attack on the Capitol. McConnell assigned blame and responsibility to Trump and said that he should be held to account through the criminal justice system for his actions.

McConnell’s critics insist he could have done more, including voting to convict Trump during his second impeachment trial. McConnell did not, arguing that since Trump was no longer in office, he could not be subject to impeachment.

Rather than fade from prominence after the Capitol riot, Trump continued to assert his control over the party, and finds himself on a clear glidepath to the Republican nomination. Other members of the Republican Senate leadership have endorsed Trump. McConnell has not, and that has drawn criticism from other Republican senators.

“I still have enough gas in the tank to thoroughly disappoint my critics and I intend to do so with all the enthusiasm which they have become accustomed.”

The Associated Press contributed to this story.